Effect of carrier size and mechanical properties on adhesive unit stability for inhalation: A numerical study

The Discrete Element Method (DEM) was used to investigate the micromechanics of adhesive units, building blocks mixtures, comprising a carrier particle with attached micronised fine particles. Binary head-on collisions between units performed in handling and dispersion velocity regimes, variations mechanical properties (mannitol or lactose) size (50, 100, 200 ?m). system modeled spherical particles interactions represented by Hertz-Mindlin Johnson-Kendall-Roberts contact models. results were analysed terms stability ratios (retention, loss transfer) (restitution coefficient). It observed that mannitol are more stable than lactose similar performance ?m is most among investigated. provide parametric knowledge about could be for development macro models engineering optimization formulations. • Adhesive different sizes formed silico. 50 ?m, 100 diameter fines. Mannitol collision study flowability segregation. unit stable.